Lipopolysaccharide (LPS) may play an important role in chronic diseases through the activation of inflammatory responses. The type of diet consumed is of major concern for the prevention and treatment of these diseases. Evidence from animal and human studies has shown that LPS can diffuse from the gut to the circulatory system in response to the intake of high amounts of fat. The method by which LPS move into the circulatory system is either through direct diffusion due to intestinal paracellular permeability or through absorption by enterocytes during chylomicron secretion. Considering the impact of metabolic diseases on public health and the association between these diseases and the levels of LPS in the circulatory system, this review will mainly discuss the current knowledge about high-fat diets and subclinical inflammation. It will also describe the new evidence that correlates gut microbiota, intestinal permeability and alkaline phosphatase activity with increased blood LPS levels and the biological effects of this increase, such as insulin resistance. Although the majority of the studies published so far have assessed the effects of dietary fat, additional studies are necessary to deepen the understanding of how the amount, the quality and the structure of the fat may affect endotoxaemia. The potential of food combinations to reduce the negative effects of fat intake should also be considered in future studies. In these studies, the effects of flavonoids, prebiotics and probiotics on endotoxaemia should be investigated. Thus, it is essential to identify dietetic strategies capable of minimising endotoxaemia and its postprandial inflammatory effects.Key words: High-fat diets: Lipopolysaccharides: Gut microbiota: Intestinal permeabilityThe role of gut microbiota in the development of diseases such as obesity (1) , diabetes (2) and atherosclerosis (3) has received increased attention from researchers worldwide. These diseases share a common mechanism because the activation of the immune system leads to greater inflammation (4 -9) . Components originating from gut microbiota, such as lipopolysaccharide (LPS), lipoteichoic acid, peptidoglycan, flagellin and bacterial DNA, can cause immune system activation. LPS is thought to be a major inducer of the inflammatory response, suggesting a possible association between intestinal LPS and these metabolic diseases (10 -13) .LPS is one of the main components of the external cell wall of Gram-negative bacteria. Therefore, the gut microbiota is a huge reservoir of this endotoxin (14) . There are 10 12 bacterial cells in each gram of faeces (15) . Consequently, it is possible to detect more than 1 g of LPS in the intestinal lumen (16,17) . Under normal conditions, the presence of LPS in the intestinal lumen does not cause negative health effects (18) . However, some factors can favour the transfer of LPS into the circulatory system. It has been suggested that the type of diet consumed, especially high-fat diets, can contribute to endotoxaemia, which is caused b...

O estresse oxidativo decorre de um desequilíbrio entre a geração de compostos oxidantes e a atuação dos sistemas de defesa antioxidante. A geração de radicais livres e/ou espécies reativas não radicais é resultante do metabolismo de oxigênio. A mitocôndria, por meio da cadeia transportadora de elétrons, é a principal fonte geradora. O sistema de defesa antioxidante tem a função de inibir e/ou reduzir os danos causados pela ação deletéria dos radicais livres e/ou espécies reativas não radicais. Esse sistema, usualmente, é dividido em enzimático (superóxido dismutase, catalase e glutationa peroxidase) e não-enzimático. No último caso, é constituído por grande variedade de substâncias antioxidantes, que podem ter origem endógena ou dietética. Objetivou-se revisar os principais mecanismos de geração de radicais livres, bem como a ação dos agentes mais relevantes do sistema de defesa antioxidante, ressaltando suas implicações sobre os marcadores do estresse oxidativo. Também serão abordados os principais fatores exógenos moduladores do estresse oxidativo. Termos de indexação:Antioxidantes. Espécies reativas de nitrogênio. Espécies reativas de oxigênio. Estresse oxidativo. Radicais livres.

No abstract

Dietary fat strongly affects human health by modulating gut microbiota composition and low-grade systemic inflammation. High-fat diets have been implicated in reduced gut microbiota richness, increased Firmicutes to Bacteroidetes ratio, and several changes at family, genus and species levels. Saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA) and conjugated linolenic fatty acids share important pathways of immune system activation/inhibition with gut microbes, modulating obesogenic and proinflammatory profiles. Mechanisms that link dietary fat, gut microbiota and obesity are mediated by increased intestinal permeability, systemic endotoxemia, and the activity of the endocannabinoid system. Although the probiotic therapy could be a complementary strategy to improve gut microbiota composition, it did not show permanent effects to treat fat-induced dysbiosis. Based upon evidence to date, we believe that high-fat diets and SFA consumption should be avoided, and MUFA and omega-3 PUFA intake should be encouraged in order to regulate gut microbiota and inflammation, promoting body weight/fat control.

The objective of the present study was to evaluate, by means of a systematic literature review, the adherence and motivation presented by diabetic patients that participate in health intervention programs, which stimulate the adoption of a healthy life style. The ingestion of an adequate diet and the increase in physical activity, focusing in the disease perception, considering the diabetic patient knowledge, making evident the recommendations that should be followed to reach a better life quality, demonstrating that it is possible to live well even if you have a chronic disease such as diabetes. A literature research in the main public health databases (Medline, Lilacs, Scielo, among others) was conducted from 1994 to 2006. A total of 37 studies focused in the interaction among the subject health and disease versus diabetes were selected. This study mentions some daily difficulties felt by the diabetic patient and his family to control the disease. These difficulties can directly affect the patient adhesion to the prescribed treatment. Therefore, the behavioral and emotional factors presented by each patient must be considered when the health activities are being planned to reach total assistance to this population.

ResumenIntroducción: la nutrición parenteral (NP) en la infancia es un tratamiento cuyas características son muy variables en función de la edad y la patología que presente el paciente. Material y métodos: el grupo de Estandarización y Protocolos de la Sociedad Española de Nutrición Parenteral y Enteral (SENPE) es un grupo interdisciplinar formado por miembros de la SENPE, Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica (SEGHNP) y Sociedad Española de Farmacia Hospitalaria (SEFH) que pretende poner al día este tema. Para ello, se ha realizado una revisión pormenorizada de la literatura buscando las evidencias que nos permiten elaborar una Guía de Práctica Clínica siguiendo los criterios del Oxford Centre for Evidence-Based Medicine. Resultados: este manuscrito expone de forma resumida las recomendaciones en cuanto a indicaciones, vías de acceso, requerimientos, modifi caciones en situaciones especiales, componentes de las mezclas, prescripción y estandarización, preparación, administración, monitorización, complicaciones y NP domiciliaria. El documento completo se publica como número monográfi co. Conclusiones: esta guía pretende servir de apoyo para la prescripción de la NP pediátrica. Constituye la base para tomar decisiones en el contexto de la evidencia existente. Ninguna guía puede tener en cuenta todas las circunstancias clínicas individuales. Abstract

Perfil sociossanitário e estilo de vida de hipertensos e/ou diabéticos, usuários do Programa de Saúde da Família no município de Teixeiras, MG

Red meat consumption was cross-sectionally associated with the occurrence of central obesity, hypertriglyceridaemia, and metabolic syndrome as well as with higher homeostatic model assessment for insulin resistance, oxidized low-density lipoprotein concentrations and triglycerides:high-density lipoprotein cholesterol ratio. The content of saturated fatty acid from red meat consumption may be a factor that contributed to this relationship, while white meat consumption was not associated with metabolic syndrome and the assessed biomarkers.