Aconitine poisoning following the ingestion of Chinese herbal medicines: a report of eight cases

Chan, T. Y. K.; Tomlinson, Brian; Critchley, J. A. J. H.

doi:10.1111/j.1445-5994.1993.tb01730.x

Cited by 87 publications

(85 citation statements)

References 9 publications

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“…Aconitine, which could be isolated from Aconitum carmichaeli and is potentially toxic [5] , was identified as "Aco peak" in chromatogram. The average quality of aconitine was 1.15 ± 0.10 μg per 7.5 g extracts (max dose of one day).…”

Section: Resultsmentioning

confidence: 99%

Effects of aqueous extracts ofAconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginsengandGekko swinhonis Gūentheron Bel-7402 cells

Zhu

Chen

et al. 2007

WJG

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AIM:To investigate the anticancer activity of a chinese medical mixture, WRCP (warming and relieving Cold Phlegm), on hepatocarcinoma Bel-7402 cells. METHODS:Fingerprints of WRCP, which were composed of aqueous extracts of Aconitum carmichaeli , Rhizoma bolbostemmatis , Phytolacca acinosa , Panax notoginseng and Gekko swinhonis Gūenther , and aconitine, which could be isolated from Aconitum carmichaeli and have the potential toxicity, were identified by high pressure liquid chromatography. Bel-7402 cells were grown in the presence of WRCP, As2O3 or all-trans-retinoic acid (ATRA). Cell proliferation and viability were determined by trypan blue stain. Apoptosis and cell cycle of Bel-7402 cells were detected by flow cytometry. Morphologic and ultrastructural variations were determined under optic and electronic microscopy. The secretion of alpha-f e t opr ot e in and albumin was detected by radioimmunoassay. RESULTS:The average quality of aconitine is 1.15 ± 0.10 μg per 7.5 g extracts. WRCP could suppress the proliferation and viability of Bel-7402 cells. The percentage of apoptosis cells and S phase cells increased on WRCP-treated cells. Treated with WRCP, Bel-7402 cells showed ultrastructural features of differentiation. The alpha-fetoprotein secretion decreased while the albumin secretion increased (P < 0.001, P < 0.001, respectively) markedly in WRCP-treated cells. CONCLUSION:WRCP can affect the proliferation, differentiation and apoptosis of Bel-7402 cells. It can arrest cells in S phase and has strong cytotoxicity to Bel-7402 cells.

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Section: Resultsmentioning

confidence: 99%

Effects of aqueous extracts ofAconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginsengandGekko swinhonis Gūentheron Bel-7402 cells

Zhu

Chen

et al. 2007

WJG

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“…Overall, five adverse effects were common to all these recipes; these were diarrhoea, abdominal pains, polyuria, general weakness and vomiting. Some studies reported that these were the main adverse effects often encountered after consuming vegetable drugs (Togola et al, 2005;Castot et al, 1997;Chan et al, 1994). Indeed, Langasou et al (1994) reported that gastroenteritis was the main adverse effect linked to the oral administration of plant-based remedies.…”

Section: Discussionmentioning

confidence: 99%

Herbal Remedies And Their Adverse Effects In Tem Tribe Traditional Medicine In Togo

Tchacondo¹,

Karou²,

Batawila³

et al. 2010

Afr. J. Trad. Compl. Alt. Med.

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In Africa, up to 80% of the population relies on herbal concoctions for their primarily health care. In Togo, western Africa, Tem tribe is a population with old knowledge of medicinal plants, however, still very little is known about their medical practices. The present study was conducted to access for the apprehension of adverse effects of traditional remedies by Tem traditional healers (TH). Enquiry was performed by interviews with healers from August to October 2007 in Tchaoudjo prefecture (Togo). The study allowed us to interview 54 TH including 41(75.93%) males and 13(24.07%) females, who cited 102 recipes assumed to have adverse effects. The recipes were used alone to cure several diseases including haemorrhoids (22.55%), female sexual disorders and infertility (21.57%), gastrointestinal disorders (18.63%), and malaria (6.86%). A total of 34 plants belonging to 21 families were cited to be components of the recipes. Euphorbiaceae and Mimosaceae families were the most represented, however, Nauclea latifolia, Khaya senegalensis, Pseudocedrela kotschyi and Xeroderris stuhlmannii were the main components of recipes linked to adverse effects. A total of 20 adverse effects were linked to the administration of theses drugs, and among them; diarrhoea, abdominal pains, polyuria, general weakness and vomiting were the most frequently encountered. These findings were in accordance with several reports of the literature concerning medicinal plants, although they were based on empirical observations. Laboratory screenings are needed to access for the effectiveness as well as the possible toxic effects of the recipes.

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“…The main root of Aconitum carmichaelli has been used in Chinese herbal medications mainly for the treatment of musculoskeletal disorders, and the herbal formulations containing it have been used for the treatment of rheumatism and heart failure as well as improvement of the immune system and retarding aging [16,17]. The plant contained the highly toxic C19 diterpenoid alkaloids of aconitine, mesaconitine and hypaconitine.…”

Section: Resultsmentioning

confidence: 99%

Screening of Korean medicinal plants for possible osteoclastogenesis effects in vitro

et al. 2007

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Bone undergoes continuous remodeling through bone formation and resorption, and maintaining the balance for skeletal rigidity. Bone resorption and loss are generally attributed to osteoclasts. Differentiation of osteoclasts is regulated by receptor activator of nuclear factor NF-kB ligand (RANKL), a member of tumor necrosis factor family. When the balance is disturbed, pathological bone abnormality ensues. Through the screening of traditional Korean medicinal plants, the effective molecules for inhibition and stimulation of RANKL-induced osteoclast differentiation in mouse bone marrow macrophages were identified. Among 222 methanol extracts, of medicinal plants, 10 samples exhibited ability to induce osteoclast differentiation. These include Dryobalanops aromatica, Euphoria longana, Lithospermum erythrorhizon, Prunus mume, Prunus nakaii, and Polygonatum odoratum. In contrast, Ailanthus altissima, Curcuma longa, Solanum nigrum, Taraxacum platycarpa, Trichosanthes kirilowii, and Daphne genkwa showed inhibitory effects in RANKLinduced osteoclast differentiation.

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Aconitine poisoning following the ingestion of Chinese herbal medicines: a report of eight cases

Cited by 87 publications

References 9 publications

Effects of aqueous extracts ofAconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginsengandGekko swinhonis Gūentheron Bel-7402 cells

Effects of aqueous extracts ofAconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginsengandGekko swinhonis Gūentheron Bel-7402 cells

Herbal Remedies And Their Adverse Effects In Tem Tribe Traditional Medicine In Togo

Screening of Korean medicinal plants for possible osteoclastogenesis effects in vitro

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