Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder

Thome, Janine; Densmore, Maria; Frewen, Paul A.; McKinnon, Margaret C.; Théberge, Jean; Nicholson, Andrew A.; Koenig, Julian; Thayer, Julian F.; Lanius, Ruth A.

doi:10.1002/hbm.23340

Cited by 76 publications

(60 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other studies, however, have found increases in rsFC of the precentral gyrus with key central autonomic network areas in PTSD (Thome et al, 2017). Here, whereas greater pulvinar-precentral connectivity in controls may indicate higher transmission of voluntary motor commands, the increased precentral and autonomic network connectivity described by Thome et al (2017) may describe greater subcortically driven, involuntary motor projections. Here, whereas greater pulvinar-precentral connectivity in controls may indicate higher transmission of voluntary motor commands, the increased precentral and autonomic network connectivity described by Thome et al (2017) may describe greater subcortically driven, involuntary motor projections.…”

Section: Pulvinar Connectivity With Pre-and Post-central Gyruscontrasting

confidence: 48%

“…Decreased connectivity of the precentral gyrus and the anterior cingulate cortex has been reported at rest in PTSD (Kennis, Rademaker, van Rooij, Kahn, & Geuze, 2015). Other studies, however, have found increases in rsFC of the precentral gyrus with key central autonomic network areas in PTSD (Thome et al, 2017). Other studies, however, have found increases in rsFC of the precentral gyrus with key central autonomic network areas in PTSD (Thome et al, 2017).…”

Section: Pulvinar Connectivity With Pre-and Post-central Gyrusmentioning

confidence: 92%

See 1 more Smart Citation

Resting‐state pulvinar‐posterior parietal decoupling in PTSD and its dissociative subtype

Terpou

Densmore

Théberge

et al. 2018

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

Key evidence points toward alterations in the neurocircuitry of large-scale networks among patients with posttraumatic stress disorder (PTSD). The pulvinar is a thalamic region displaying reciprocal connectivity with the cortex and has been shown to modulate alpha synchrony to facilitate network communication. During rest, the pulvinar displays functional connectivity with the posterior parietal cortex (PPC), a heteromodal network of brain areas underlying multisensory integration and socioaffective functions that are shown at deficit in PTSD. Accordingly, this study seeks to reveal the resting-state functional connectivity (rsFC) patterns of individuals with PTSD, its dissociative subtype (PTSD + DS) and healthy controls. A whole-brain rsFC analysis was conducted using SPM12 and PickAtlas. Connectivity was analyzed for the left and right pulvinar across groups of individuals with PTSD (n = 81), PTSD + DS (n = 49), and controls (n = 51). As compared to PTSD, controls displayed significantly greater pulvinar rsFC with the superior parietal lobule and precuneus. Moreover, as compared to PTSD + DS, controls showed increased pulvinar connectivity with the superior parietal lobule, inferior parietal lobule and the precuneus. PTSD groups did not display stronger connectivity with any region as compared to controls. Last, PTSD had greater rsFC in the supramarginal gyrus relative to PTSD + DS. Reduced connectivity between the pulvinar and PPC may explain impairments to autobiographical memory, self-referential processing, and socioaffective domains in PTSD and PTSD + DS even at "rest." Critically, these alterations appear to be exacerbated in individuals with PTSD + DS, which may have important implications for treatment.

show abstract

Section: Pulvinar Connectivity With Pre-and Post-central Gyruscontrasting

confidence: 48%

Section: Pulvinar Connectivity With Pre-and Post-central Gyrusmentioning

confidence: 92%

Resting‐state pulvinar‐posterior parietal decoupling in PTSD and its dissociative subtype

Terpou

Densmore

Théberge

et al. 2018

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

show abstract

“…By contrast, decreased baseline activity (amplitude of low‐frequency fluctuation) characterized lobule VI in PTSD as compared to trauma‐exposed controls (Yin et al, ). Furthermore, increased resting‐state functional connectivity between the anterior vermis and the amygdala and the periaqueductal grey (Thome et al, ) emerged in PTSD as compared to healthy controls, where decreased functional connectivity between the posterior vermis and the medial prefrontal cortex correlated positively with PTSD symptomatology. Taken together, these studies point toward a crucial role of the cerebellum in the psychopathology of PTSD (Carletto & Borsato, 2017), which is evident not only during exposure to trauma cues but also during resting state.…”

Section: Introductionmentioning

confidence: 99%

The cerebellum after trauma: Resting‐state functional connectivity of the cerebellum in posttraumatic stress disorder and its dissociative subtype

Rabellino

Densmore

Théberge

et al. 2018

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

The cerebellum plays a key role not only in motor function but also in affect and cognition. Although several psychopathological disorders have been associated with overall cerebellar dysfunction, it remains unclear whether different regions of the cerebellum contribute uniquely to psychopathology. Accordingly, we compared seed-based resting-state functional connectivity of the anterior cerebellum (lobule IV-V), of the posterior cerebellum (Crus I), and of the anterior vermis across posttraumatic stress disorder (PTSD; n = 65), its dissociative subtype (PTSD + DS; n = 37), and non-trauma-exposed healthy controls (HC; n = 47). Here, we observed decreased functional connectivity of the anterior cerebellum and anterior vermis with brain regions involved in somatosensory processing, multisensory integration, and bodily self-consciousness (temporo-parietal junction, postcentral gyrus, and superior parietal lobule) in PTSD + DS as compared to PTSD and HC. Moreover, the PTSD + DS group showed increased functional connectivity of the posterior cerebellum with cortical areas related to emotion regulation (ventromedial prefrontal and orbito-frontal cortex, subgenual anterior cingulum) as compared to PTSD. By contrast, PTSD showed increased functional connectivity of the anterior cerebellum with cortical areas associated with visual processing (fusiform gyrus), interoceptive awareness (posterior insula), memory retrieval, and contextual processing (hippocampus) as compared to HC. Finally, we observed decreased functional connectivity between the posterior cerebellum and prefrontal regions involved in emotion regulation, in PTSD as compared to HC. These findings not only highlight the crucial role of each cerebellar region examined in the psychopathology of PTSD but also reveal unique alterations in functional connectivity distinguishing the dissociative subtype of PTSD versus PTSD.

show abstract

“…Moreover, enhanced functional connectivity between the PAG and salience processing areas (e.g. dACC and anterior insula) was observed in PTSD (Harricharan et al, 2016; Thome et al, 2017). Neural control over autonomic responses is exerted by various brain regions comprising the central autonomic network, including the amygdala, brainstem, vmPFC and dACC (Critchley, Nagai, Gray, & Mathias, 2011; Etkin, Egner, & Kalisch, 2011; Thayer, Åhs, Fredrikson, Sollers, & Wager, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Neural control over autonomic responses is exerted by various brain regions comprising the central autonomic network, including the amygdala, brainstem, vmPFC and dACC (Critchley, Nagai, Gray, & Mathias, 2011; Etkin, Egner, & Kalisch, 2011; Thayer, Åhs, Fredrikson, Sollers, & Wager, 2012). Autonomic dysregulations in PTSD, as measured with decreased high-frequency heart rate variability (HF-HRV), was associated with altered activity and desynchronized functional connectivity of brain regions involved in autonomic regulation, respectively during presentation of trauma-related stimuli (Rabellino et al, 2017) and during rest (Thome et al, 2017). …”

Section: Introductionmentioning

confidence: 99%

The role of automatic defensive responses in the development of posttraumatic stress symptoms in police recruits: protocol of a prospective study

Koch

Klumpers

Zhang

et al. 2017

European Journal of Psychotraumatology

View full text Add to dashboard Cite

Background: Control over automatic tendencies is often compromised in challenging situations when people fall back on automatic defensive reactions, such as freeze – fight – flight responses. Stress-induced lack of control over automatic defensive responses constitutes a problem endemic to high-risk professions, such as the police. Difficulties controlling automatic defensive responses may not only impair split-second decisions under threat, but also increase the risk for and persistence of posttraumatic stress disorder (PTSD) symptoms. However, the significance of these automatic defensive responses in the development and maintenance of trauma-related symptoms remains unclear due to a shortage of large-scale prospective studies. Objective: The ‘Police-in-Action’ study is conducted to investigate the role of automatic defensive responses in the development and maintenance of PTSD symptomatology after trauma exposure. Methods: In this prospective study, 340 police recruits from the Dutch Police Academy are tested before (wave 1; pre-exposure) and after (wave 2; post-exposure) their first emergency aid experiences as police officers. The two waves of data assessment are separated by approximately 15 months. To control for unspecific time effects, a well-matched control group of civilians (n = 85) is also tested twice, approximately 15 months apart, but without being frequently exposed to potentially traumatic events. Main outcomes are associations between (changes in) behavioural, psychophysiological, endocrine and neural markers of automatic defensive responses and development of trauma-related symptoms after trauma exposure in police recruits. Discussion: This prospective study in a large group of primary responders enables us to distinguish predisposing from acquired neurobiological abnormalities in automatic defensive responses, associated with the development of trauma-related symptoms. Identifying neurobiological correlates of (vulnerability for) trauma-related psychopathology may greatly improve screening for individuals at risk for developing PTSD symptomatology and offer valuable targets for (early preventive) interventions for PTSD.

show abstract

Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder

Abstract: This study provides the first evidence for a specific psychophysiological-neuronal profile in PTSD individuals characterized by lower resting HRV and a lack of HRV covariation with CAN-related brain connectivity. Hum Brain Mapp 38:27-40, 2017. © 2016 Wiley Periodicals, Inc.

Cited by 76 publications

References 88 publications

Resting‐state pulvinar‐posterior parietal decoupling in PTSD and its dissociative subtype

Resting‐state pulvinar‐posterior parietal decoupling in PTSD and its dissociative subtype

The cerebellum after trauma: Resting‐state functional connectivity of the cerebellum in posttraumatic stress disorder and its dissociative subtype

The role of automatic defensive responses in the development of posttraumatic stress symptoms in police recruits: protocol of a prospective study

Contact Info

Product

Resources

About