We present a method for increasing the lateral chain density in self-assembled monolayers (SAMs) of alkanethiols on polycrystalline gold. This method relies on exposure of the alkanethiolate monolayers to mercury vapor and subsequent reimmersion into the thiol solution. Mercury adsorption on the gold surface induces a structural rearrangement in the alkanethiolate monolayers, as indicated by changes in dichroism in the Fourier transform infrared (FTIR) spectra, in line shape in the sum frequency generation (SFG) spectra, and in the macroscopic wetting behavior of the monolayers. X-ray photoelectron spectroscopy (XPS) data show that saturation of the thiolate samples with mercury occurs after 20−30 min of exposure to air saturated with mercury vapor. For 100 nm evaporated gold films a mercury bulk concentration of 14−16 atom % was determined by energy-dispersive X-ray analysis (EDX). Time-of-flight secondary ion mass spectroscopy (ToF-SIMS) data indicate that after mercury adsorption the monolayers consist of gold thiolate and mercury thiolate molecules. From the FTIR and XPS data we conclude that the mercury-exposed SAMs exhibit an inhomogeneous structure with differently tilted domains. As determined from the IR experiments, the average tilt angle of the alkyl chains in hexadecanethiolate monolayers decreases by ∼16° by mercury adsorption and by an additional ∼3° after reimmersion into the thiol solution. The corresponding changes obtained from near edge X-ray absorption fine structure (NEXAFS) spectra are ∼9° and ∼3°, respectively.
Persistent loneliness is often reported by patients with borderline personality disorder (BPD). However, empirical studies investigating this aspect of BPD psychopathology are sparse. Studies from social psychology revealed that social isolation and low social functioning contribute to loneliness, that is, the subjective feeling of being alone. The aim of the present study was to contribute to the understanding of loneliness in BPD by investigating its relation to social isolation and functioning in different domains of life. Subjective experience of loneliness was measured in 80 women (40 BPD patients, 40 healthy controls) with the UCLA Loneliness Scale. Social isolation and social functioning were assessed with the Social Network Inventory and the Social Functioning Scale. In addition, we assessed global functioning with the Global Assessment of Functioning. BPD patients reported stronger feelings of loneliness compared to healthy participants. In general, the level of loneliness was linked to network size, social engagement, and prosocial behavior. Diversity of social networks and functioning in the domain of interpersonal communication were associated with the level of loneliness only in BPD. A reduced variety of roles in social life together with impairments in interpersonal communication were particularly relevant for the experience of loneliness in BPD, suggesting an indirect path to target this psychopathological feature in therapeutic interventions. However, both social isolation and social functioning were not sufficient to explain the severely increased loneliness experienced by these patients, stressing the need for further investigation of determinants of loneliness in this clinical population. (PsycINFO Database Record
This review examines recent functional neuroimaging research of resting-state regional connectivity between brain regions in anxiety disorders. Studies compiled in the PubMedNational Center for Biotechnology Information database targeting resting-state functional connectivity in anxiety disorders were reviewed. Diagnoses included posttraumatic stress disorder (PTSD), generalized anxiety disorder (GAD), social anxiety disorder (SAD), obsessive-compulsive disorder (OCD), panic disorder (PD), and specific phobia (SP).Alterations to network connectivity were demonstrated in PTSD, GAD, SAD, OCD, and PD in several resting-state investigations. Differences from control subjects were primarily observed in the default mode network within PTSD, SAD, and OCD. Alterations within the salience network were observed primarily in PTSD, GAD, and SAD. Alterations in corticostriatal networks were uniquely observed in OCD. Finally, alterations within somatosensory networks were observed in SAD and PD investigations. Resting-state studies involving SPs as a primary diagnosis (with or without comorbidities) were not generated during the literature search. The emerging use of resting-state paradigms may be an effective method for understanding associations between anxiety disorders. Targeted studies of PD and SPs, meta-analyses of the studies conducted to date, and studies of the impact of specific comorbid presentations, are recommended future research directions. W W W Études de neuroimagerie à l'état de repos : une nouvelle façon d'identifier les différences et les similitudes des troubles anxieux?Cette revue examine la recherche récente en neuroimagerie fonctionnelle sur la connectivité régionale à l'état de repos entre les régions du cerveau dans les troubles anxieux. Des études de la base de données PubMed-National Center for Biotechnology Information portant sur la connectivité fonctionnelle à l'état de repos dans les troubles anxieux ont été examinées. Les diagnostics incluaient notamment le trouble de stress post-traumatique (TSPT), le trouble d'anxiété généralisée (TAG), le trouble d'anxiété sociale (TAS), le trouble obsessionnel-compulsif (TOC), le trouble panique (TP), et la phobie spécifique (PS). Les modifications de la connectivité du réseau ont été démontrées dans les TSPT, TAG, TAS, TOC et TP dans plusieurs investigations à l'état de repos. Les différences par rapport aux sujets témoins ont été surtout observées dans le réseau du mode par défaut dans le TSPT, le TAS, et le TOC. Les modifications du réseau de saillie ont été surtout observées dans le TSPT, le TAG, et le TAS. Les modifications des réseaux corticostriataux ont été observées seulement dans le TOC. Enfin, les modifications des réseaux somatosensoriels ont été observées dans les investigations du TAS et du TP. Les études à l'état de repos impliquant les PS comme diagnostic primaire (avec ou sans comorbidités) n'ont pas été générées durant la recherche de la littérature. L'utilisation naissante des paradigmes de l'état au repos peut se révéler une méthode ef...
A neurocircuitry model of post-traumatic stress disorder (PTSD) suggests increased amygdala responses to emotional stimuli, coupled with hypoactivation of prefrontal regions associated with cognitive control. However, results are heterogenous across different subsamples of PTSD as well as different paradigms. We investigated cognitive control in a classic and emotional Stroop task in 28 female patients with complex PTSD (cPTSD), 28 female trauma-exposed healthy controls (TCs) and 28 female non-trauma-exposed healthy controls (HCs) using functional neuroimaging. Afterwards, we assessed memory function in a spontaneous free recall and recognition task. Patients with cPTSD displayed significantly greater Stroop interference with trauma-related words (as reflected in slower reaction times and increased errors) compared to the other conditions and compared to the TC and HC groups. Moreover, patients with cPTSD showed increased activation in the context of trauma-related words in brain regions associated with cognitive control (dlPFC, vmPFC, dACC) compared to both control groups, and a trend for increased activation in the insula compared to the HC group. Increased recruitment of regions contributing to cognitive control in patients with cPTSD, together with a lack of amygdala response may point to efforts to compensate for emotional distraction caused by the trauma-related words.
This study provides the first evidence for a specific psychophysiological-neuronal profile in PTSD individuals characterized by lower resting HRV and a lack of HRV covariation with CAN-related brain connectivity. Hum Brain Mapp 38:27-40, 2017. © 2016 Wiley Periodicals, Inc.
Background Autobiographical memory (AM) refers to memories of events that are personally relevant and are remembered from one's own past. The AM network is a distributed brain network comprised largely by prefrontal medial and posteromedial cortical brain regions, which together facilitate AM. Autobiographical memories with high arousal and negatively valenced emotional states are thought to be retrieved more readily and re‐experienced more vividly. This is critical in the case of trauma‐related AMs, which are related to altered phenomenological experiences as well as aberrations to the underlying neural systems in posttraumatic stress disorder (PTSD). Critically, these alterations to the AM network have not been explored recently and have never been analyzed with consideration to the different processes of AM, them being retrieval and re‐experiencing. Methods We conducted a series of effect‐size signed differential mapping meta‐analyses across twenty‐eight studies investigating the neural correlates of trauma‐related AMs in participants with PTSD as compared with controls. Studies included either trauma‐related scripts or trauma‐related materials (i.e., sounds, images, pictures) implemented to evoke the recollection of a trauma‐related memory. Results The meta‐analyses revealed that control and PTSD participants displayed greater common brain activation of prefrontal medial and posteromedial cortices, respectively. Whereby the prefrontal medial cortices are suggested to facilitate retrieval monitoring, the posteromedial cortices are thought to enable the visual imagery processes of AM. Conclusions Taken together, reduced common activation of prefrontal cortices may be interpreted as a bias toward greater re‐experiencing, where the more salient elements of the traumatic memory are relived as opposed to retrieved in a controlled manner in PTSD.
BackgroundInterpersonal dysfunction in Borderline Personality Disorder (BPD) is characterized by an ‘anxious preoccupation with real or imagined abandonment’ (DSM-5). This symptom description bears a close resemblance to that of rejection sensitivity, a cognitive affective disposition that affects perceptions, emotions and behavior in the context of social rejection. The present study investigates the level of rejection sensitivity in acute and remitted BPD patients and its relation to BPD symptom severity, childhood maltreatment, and self-esteem.MethodsData were obtained from 167 female subjects: 77 with acute BPD, 15 with remitted BPD, and 75 healthy controls who were matched with the patients for age and education. The instruments used for assessment were the Rejection Sensitivity Questionnaire, the short version of the Borderline Symptom List, the Childhood Trauma Questionnaire, and the Rosenberg Self-Esteem Scale.ResultsBoth acute and remitted BPD patients had higher scores on the Rejection Sensitivity Questionnaire than did healthy controls. Lower self-esteem was found to be positively correlated with both increased BPD symptom severity and higher rejection sensitivity, and mediated the relation between the two. History of childhood maltreatment did not correlate with rejection sensitivity, BPD symptom severity, or self-esteem.ConclusionsOur findings support the hypothesis that rejection sensitivity is an important component in BPD, even for remitted BPD patients. Level of self-esteem appears to be a relevant factor in the relationship between rejection sensitivity and BPD symptom severity. Therapeutic interventions for BPD would do well to target rejection sensitivity.Electronic supplementary materialThe online version of this article (doi:10.1186/s40479-015-0025-x) contains supplementary material, which is available to authorized users.
Dysfunctions of social-cognitive processes such as the recognition of emotions have been discussed to contribute to the severe impairments of interpersonal functioning in borderline personality disorder (BPD). By investigating how patients with BPD experience the intensity of different emotions in a facial expression and how confident they are in their own judgments, the current study aimed at identifying subtle alterations of emotion processing in BPD. Female patients with BPD (N = 36) and 36 healthy controls were presented with faces that displayed low-intense anger and happiness or ambiguous expressions of anger and happiness blends. Subjects were asked to rate (a) the intensity of anger and happiness in each facial expression and (b) their confidence in their judgments. Patients with BPD rated the intensity of happiness in happy faces lower than did controls, but did not differ in regard to the assessment of angry or ambiguous facial stimuli or the rating of anger. They reported lower confidence in their judgments, which was particularly pronounced for the assessment of happy facial expressions. The reduced rating of happiness was linked to higher state anger, whereas the reduced confidence in the assessment of happy faces was related to stronger feelings of loneliness and the expectation of social rejection. Our findings suggest alterations in the processing of positive social stimuli that affect both the experience of the emotional intensity and the confidence subjects experience during their assessment. The link to loneliness and social rejection sensitivity points to the necessity to target these alterations in psychotherapeutical interventions.
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