Resting-State Neuroimaging Studies: A New Way of Identifying Differences and Similarities among the Anxiety Disorders?

Peterson, Andrew; Thome, Janine; Frewen, Paul A.; Lanius, Ruth A.

doi:10.1177/070674371405900602

Cited by 139 publications

(97 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In line with such a possibility, meta-analyses of the functional neuroimaging of anxiety have found heightened insula activation in PTSD, Social Anxiety Disorder and Specific Phobia compared with controls (Etkin and Wager, 2007), and in PTSD compared with both trauma-naïve and traumaexposed controls (Patel et al, 2012). Increased salience network connectivity has also been documented in a host of anxiety disorders, notably including PTSD (Peterson et al, 2014). Furthermore, propranolol-another pharmacological agent investigated as an adjunct for PTSD therapy (Brunet et al, 2008, but see Wood et al, 2015;Steenen et al, 2016)-decreases connectivity within the salience network (Hermans et al, 2011).…”

Section: Discussionmentioning

confidence: 90%

Altered Insula Connectivity under MDMA

Walpola

Nest

Roseman

et al. 2017

Neuropsychopharmacol

View full text Add to dashboard Cite

Recent work with noninvasive human brain imaging has started to investigate the effects of 3,4-methylenedioxymethamphetamine (MDMA) on large-scale patterns of brain activity. MDMA, a potent monoamine-releaser with particularly pronounced serotonin-releasing properties, has unique subjective effects that include: marked positive mood, pleasant/unusual bodily sensations and pro-social, empathic feelings. However, the neurobiological basis for these effects is not properly understood, and the present analysis sought to address this knowledge gap. To do this, we administered MDMA-HCl (100 mg p.o.) and, separately, placebo (ascorbic acid) in a randomized, doubleblind, repeated-measures design with twenty-five healthy volunteers undergoing fMRI scanning. We then employed a measure of global resting-state functional brain connectivity and follow-up seed-to-voxel analysis to the fMRI data we acquired. Results revealed decreased right insula/salience network functional connectivity under MDMA. Furthermore, these decreases in right insula/salience network connectivity correlated with baseline trait anxiety and acute experiences of altered bodily sensations under MDMA. The present findings highlight insular disintegration (ie, compromised salience network membership) as a neurobiological signature of the MDMA experience, and relate this brain effect to trait anxiety and acutely altered bodily sensations-both of which are known to be associated with insular functioning.

show abstract

Section: Discussionmentioning

confidence: 90%

Altered Insula Connectivity under MDMA

Walpola

Nest

Roseman

et al. 2017

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…23,30 It has been inversely associated with symptom severity. 23 Insula–amygdala hypoconnectivity, which is correlated with anxious avoidance, has also been observed (figure 2).…”

Section: Salience Circuitmentioning

confidence: 99%

“…23 Hyper-connectivity between the insula and anterior nodes of the default mode circuit (figure 2) has been reported in both depression 23 and social anxiety disorder. 30 Dorsal nodes of the salience circuit show both hyper connectivity and hypoconnectivity with the posterior precuneus node of the attention circuit (figure 2). 31 The direction of altered connectivity between salience and attention circuits can fluctuate with the nature of interoceptive or external events, consistent with the view that the salience-circuit guides the switching of attention according to stimulus importance.…”

Section: Salience Circuitmentioning

confidence: 99%

Precision psychiatry: a neural circuit taxonomy for depression and anxiety

Williams

2016

The Lancet Psychiatry

449

323

View full text Add to dashboard Cite

Although there have been tremendous advances in the understanding of human dysfunctions in the brain circuitry for self-reflection, emotion, and cognitive control, a brain-based taxonomy for mental disease is still lacking. As a result, these advances have not been translated into actionable clinical tools, and the language of brain circuits has not been incorporated into training programmes. To address this gap, I present this synthesis of published work, with a focus on functional imaging of circuit dysfunctions across the spectrum of mood and anxiety disorders. This synthesis provides the foundation for a taxonomy of putative types of dysfunction, which cuts across traditional diagnostic boundaries for depression and anxiety and includes instead distinct types of neural circuit dysfunction that together reflect the heterogeneity of depression and anxiety. This taxonomy is suited to specifying symptoms in terms of underlying neural dysfunction at the individual level and is intended as the foundation for building mechanistic research and ultimately guiding clinical practice.

show abstract

“…In the long run, understanding these mechanisms will greatly inform both how to identify those at risk for certain clusters of PTSD symptoms, and how to tailor individual treatments for the best recovery outcomes. Brain structure and function, along with genetics, have emerged as important biological markers of PTSD, helping to identify risk for this disorder and further linking a complex cluster of behaviors to mechanisms of dysfunction and recovery (Greco & Liberzon, 2016; Michopoulos et al, 2015; Peterson et al, 2014; Stark et al, 2015). Combining the two methodologies of neuroimaging and genetics, however, offers an opportunity for an even more nuanced mechanistic understanding of PTSD (Bogdan et al, 2016).…”

mentioning

confidence: 99%

Neuroimaging genetic approaches to Posttraumatic Stress Disorder

Lebois

Wolff

Ressler

2016

Experimental Neurology

View full text Add to dashboard Cite

Neuroimaging genetic studies that associate genetic and epigenetic variation with neural activity or structure provide an opportunity to link genes to psychiatric disorders, often before psychopathology is discernable in behavior. Here we review neuroimaging genetics studies with participants who have Posttraumatic Stress Disorder (PTSD). Results show that genes related to the physiological stress response (e.g., glucocorticoid receptor and activity, neuroendocrine release), learning and memory (e.g., plasticity), mood, and pain perception are tied to neural intermediate phenotypes associated with PTSD. These genes are associated with and sometimes predict neural structure and function in areas involved in attention, executive function, memory, decision-making, emotion regulation, salience of potential threats, and pain perception. Evidence suggests these risk polymorphisms and neural intermediate phenotypes are vulnerabilities toward developing PTSD in the aftermath of trauma, or vulnerabilities toward particular symptoms once PTSD has developed. Work distinguishing between the re-experiencing and dissociative subtypes of PTSD, and examining other PTSD symptom clusters in addition to the re-experiencing and hyperarousal symptoms, will further clarify neurobiological mechanisms and inconsistent findings. Furthermore, an exciting possibility is that genetic associations with PTSD may eventually be understood through differential intermediate phenotypes of neural circuit structure and function, possibly underlying the different symptom clusters seen within PTSD.

show abstract

Resting-State Neuroimaging Studies: A New Way of Identifying Differences and Similarities among the Anxiety Disorders?

Cited by 139 publications

References 59 publications

Altered Insula Connectivity under MDMA

Altered Insula Connectivity under MDMA

Precision psychiatry: a neural circuit taxonomy for depression and anxiety

Neuroimaging genetic approaches to Posttraumatic Stress Disorder

Contact Info

Product

Resources

About