High signal intensity on magnetic resonance imaging is a better predictor of neurobehavioral performances than blood manganese in asymptomatic welders

Chang, Yongmin; Kim, Yangho; Woo, Sung-Ho; Song, Hyohak; Kim, Suk Hwan; Lee, Hun; Kwon, Young Joo; Ahn, Jong Joon; Park, Sin-Jae; Chung, In-Sung; Jeong, Kyoung Sook

doi:10.1016/j.neuro.2009.04.002

Cited by 81 publications

(79 citation statements)

References 40 publications

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“…The results have not shown the differences between the MRI scans and the control group workers but a significant difference was seen in the case of testing the blood of these individuals for Mn as compared to the control group [13]. The objectives of this study have been to evaluate Mn occupational exposure by measuring Mn concentration and finding correlation of Mn pollution and indoor psychometric parameters, such as dry bulb temperature (Td), relative humidity (RH), air velocity (or wind speed) and altitude in the foundry factory.…”

Section: Introductionmentioning

confidence: 69%

“…In another study done by Chang et al [13] on workers exposed to manganese fume, they compared the results of the evaluation by magnetic resonance imaging (MRI) scans and neurological testing area of the brain and the results of serum manganese and workers and the control group (N = 43) [13]. The results have not shown the differences between the MRI scans and the control group workers but a significant difference was seen in the case of testing the blood of these individuals for Mn as compared to the control group [13].…”

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

“…One of the most important scientific methods, particularly to determine the exposure to pollutants, is biological monitoring of workplaces [13][14][15]. Bio-monitoring methods are usually carried out in a limited period of time and in certain circumstances of the level of pollutants concentration in blood plasma, search, urine, feces, nails, etc., using laboratory analysis equipment [13][14][15]. According to studies, pollution criteria for exposed people were ≥ 4 μg/ml concentrations of Mn in subjects' blood; for the pollutants poisoning workers, 1-4 μg/l has been set as an indicator of normal range [7,16,17].…”

Section: Introductionmentioning

confidence: 99%

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Correlation between airborne manganese concentration at the workstations in the iron foundry and manganese concentration in workers’ blood

Mirmohammadi¹,

Moghaddasi²,

Yazdani³

et al. 2017

Med Pr

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Background: Manganese (Mn) used as raw material for melting process in the ferrous foundry is considered as hazardous neurotoxic substance because it accumulates in the central nervous system and may cause neurological disorders. The furnace-men and melting department workers are potentially exposed to manganese particles or fume in the workplace. The objective of the research has been to investigate the sources and levels of manganese exposure in the foundry by correlation of blood-manganese (B-Mn) and air-manganese (air-Mn) measurement. Material and Methods: Air-Mn and Mn of blood serum were measured involving workers who worked in a big-sized foundry during 1 year. The standard method of the Occupational Safety and Health Administration (OSHA) ID-121 was used for air and blood assessment and atomic absorption spectroscopy (AAS) was carried out for air and blood sample analysis. Results: The air sampling results have revealed that there is a high exposure to manganese (4.5 mg/m 3 ) in the workplace as compared to the National Institute for Occupational Safety and Health's (NIOSH) time weighted average (the reference time-weighted average (TWA) = 1 mg/m 3 ). The average blood serum Mn concentration was 2.745 μg/l for subjects working for shorter than 3 months and 274.85 μg/l for subjects working 3-12 months. Conclusions: Against the research hypothesis there was no correlation between the air-Mn concentration and the B-Mn (serum) level of manganese in the serum of the exposed subjects. It may be due to short time of air sampling of manganese airborne particles, and a real-time monitoring of airborne manganese particles is suggested for any future study. Med Pr 2017;68(4): [449][450][451][452][453][454][455][456][457][458]

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Section: Introductionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Correlation between airborne manganese concentration at the workstations in the iron foundry and manganese concentration in workers’ blood

Mirmohammadi¹,

Moghaddasi²,

Yazdani³

et al. 2017

Med Pr

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“…The CATSYS Tremor Pen [9] is a portable lightweight microaccelerometer that has been used in several studies for evaluation of tremor among groups of workers with occupational exposure to mercury vapour [10][11][12][13] and manganese [14][15][16][17][18][19][20][21][22]. The equipment has been validated and standardized [23,24].…”

Section: Introductionmentioning

confidence: 99%

Measuring Tremor – Does Recording Time Matter?

Wastensson¹,

Andersson²,

Bast‐Pettersen³

2016

J Neurol Neurophysiol

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Objective: The CATSYS Tremor Pen has been used in several studies for measurement of tremor among workers with occupational exposure to neurotoxins like mercury and manganese. The main purpose of this study was to investigate whether recording time has an impact on the measured tremor characteristics. Other aims were to investigate whether there are interactions between recording time and age, and between recording time and (selfreported) nicotine use, respectively; to assess the test-retest repeatability of the instrument; to investigate a possible practice effect when performing the test repeatedly; and to evaluate agreement with another tremor test. Methods:The participants (n=44) consisted of former shipyard workers (mean age 67 years, range 59-76 years). Postural hand tremor was evaluated using the CATSYS Tremor Pen. Five tremor recordings were made; the first lasted 16.4 s, the next three lasted 8.2 s each and the fifth lasted 65.6 s. Results:There was a significant association between recording time and harmonic index; longer recording time produced higher harmonic index. There was no effect of nicotine use or age that was consistent over all recording times, and no practice effect was seen. The agreement with another tremor test was moderate to good, as was the test-retest reliability. Conclusion:Some of the tremor characteristics are affected by length of recording time and hence care should be taken when comparing results across studies or with follow-up. The results indicate that the use of a recording time longer than 16.4 s seems to be of doubtful value.

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Manganese and Rhenium

Santonen¹,

Sainio²

2023

Patty's Toxicology

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Manganese (Mn) and rhenium (Re) are group 7 (VIIB) transition elements. They both can exist in multiple valence states ranging from −3 to +7. While manganese is one of the most abundant elements in the earth's crust, rhenium is one of the rarest elements. The main use of manganese is in steel production. Organic manganese compound methylcyclopentadienyl manganese tricarbonyl (MMT) is used as an additive to gasoline. Rhenium is one of the densest metals known. It is used in high‐temperature superalloys and, for example, in platinum–rhenium catalysts. Manganese is an essential nutrient and readily available from a wide variety of foods. The main target organ of manganese toxicity is the brain. Clinical adverse effects have been described in occupational settings due to inhalation of Mn fumes and dusts, but excessive manganese intake may also result from dietary, environmental, or from its dysfunctional excretion. High exposure to manganese in miners and smelters has led to manganism, that is, a severe movement disorder, cognitive dysfunction, behavioral disturbances, and loss of libido. This is due to manganese accumulation and adverse effects in the brain basal ganglia. Recognition of subtle neurobehavioral effects in workers exposed to lower levels of manganese has led to progressive actions to limit occupational exposure. Manganese exposure has shown also effects in the respiratory system, which, however, may rather be due to particulate matter than to manganese ion. High doses of manganese have affected the sperm parameters and fertility of males in animal studies. Developmental neurotoxicity studies in animals suggest that early Mn exposure may impair learning, memory, and attention of the offspring. Very few information exists on the toxicity of rhenium. Limited evidence suggests low acute toxicity of perrhenates. Perrhenates accumulate in the thyroid. Repeated exposure to ammonium perrhenate has resulted in thyroid enlargement and follicular cell hypertrophy in animals at high doses.

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High signal intensity on magnetic resonance imaging is a better predictor of neurobehavioral performances than blood manganese in asymptomatic welders

Cited by 81 publications

References 40 publications

Correlation between airborne manganese concentration at the workstations in the iron foundry and manganese concentration in workers’ blood

Correlation between airborne manganese concentration at the workstations in the iron foundry and manganese concentration in workers’ blood

Measuring Tremor – Does Recording Time Matter?

Manganese and Rhenium

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