Lactobacillus acidophilus ameliorates obesity in mice through modulation of gut microbiota dysbiosis and intestinal permeability

Kang, Yongbo; Kang, Xing; Yang, Hao; Liu, Haixia; Yang, Xiaodan; Liu, Qingqing; Tian, Haixia; Xue, Yang; Ren, Ping; Kuang, Xiaoyu; Cai, Yue; Tong, Mingwei; Lin, Li; Fan, Weiping

doi:10.1016/j.phrs.2021.106020

Cited by 85 publications

(44 citation statements)

References 51 publications

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“…In accordance with the results, Liu et al previously showed that relative abundance of the order Lactobacillales was lower (0.151%) in TRAMP mice fed with an HFD compared to those fed with a control diet (0.954%) [40]. A recent preclinical study revealed that Lactobacillus acidophilus attenuated obesity through gut dysbiosis with the reduction of endotoxemia and production of systematic anti-inflammatory molecules [41]. Another study reported in vitro cytotoxic effects of L. acidophilus LA-5 (LA-5) and L. rhamnosus GG (LGG) grown in the presence of oleuropein on human PCa cell lines [42,43].…”

Section: Discussionsupporting

confidence: 73%

Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression

Sato

Narita

Ishida

et al. 2022

IJMS

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Lard diet (LD) is a risk factor for prostate cancer (PCa) development and progression. Two immunocompetent mouse models fed with isocaloric specific fat diets (LD) enriched in saturated and monounsaturated fatty acid (SMFA), showed significanftly enhanced PCa progression with weight gain compared with a fish oil diet (FOD). High gut microbial divergency resulted from difference in diets, and the abundance of several bacterial species, such as in the orders Clostridiales and Lactobacillales, was markedly altered in the feces of LD- or FOD-fed mice. The proportion of the order Lactobacillales in the gut was negatively involved in SMFA-induced body weight gain and PCa progression. We found the modulation of lipid metabolism and cholesterol biosynthesis pathways with three and seven commonly up- and downregulated genes in PCa tissues, and some of them correlated with the abundance of the order Lactobacillales in mouse gut. The expression of sphingosine 1-phosphate receptor 2, which is associated with the order Lactobacillales and cancer progression in mouse models, was inversely associated with aggressive phenotype and weight gain in patients with PCa using the NCBI Gene Expression Omnibus database. Therefore, SMFA may promote PCa progression with the abundance of specific gut microbial species and overexpression of lipogenic genes in PCa. Therapeutics with alteration of gut microbiota and candidate genes involved in diet-induced PCa progression may be attractive in PCa.

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Section: Discussionsupporting

confidence: 73%

Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression

Sato

Narita

Ishida

et al. 2022

IJMS

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“…In addition, HFD alters the functional integrity of the ileum, and one mechanism by which HFD induces gut microbes dysbiosis by modifying peroxisome proliferator-activated receptor-γ (PPAR-γ) pathway ( Tomas et al, 2016 ). Of note, HFD-induced gut microbiome alterations are strongly associated with metabolic diseases ( Kang et al, 2022 ). Currently, intervention of gut microbiota by prebiotics can prevent or ameliorate HFD-induced metabolic diseases ( Kang et al, 2022 ).…”

Section: High-fat Diet Induces Gut Microbiota Dysbiosismentioning

confidence: 99%

“…Of note, HFD-induced gut microbiome alterations are strongly associated with metabolic diseases ( Kang et al, 2022 ). Currently, intervention of gut microbiota by prebiotics can prevent or ameliorate HFD-induced metabolic diseases ( Kang et al, 2022 ). Of note, characterization of intestinal microbiota profiles prior to dietary intervention by prebiotics will increase the positive outcome in patients with metabolic disorders ( Rodriguez et al, 2020 ).…”

Section: High-fat Diet Induces Gut Microbiota Dysbiosismentioning

confidence: 99%

Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions Against High-Fat Diet-Induced Metabolic Diseases

et al. 2022

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Unhealthy diet, in particular high-fat diet (HFD) intake, can cause the development of several metabolic disorders, including obesity, hyperlipidemia, type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome (MetS). These popular metabolic diseases reduce the quality of life, and induce premature death worldwide. Evidence is accumulating that the gut microbiota is inextricably associated with HFD-induced metabolic disorders, and dietary intervention of gut microbiota is an effective therapeutic strategy for these metabolic dysfunctions. Polysaccharides are polymeric carbohydrate macromolecules and sources of fermentable dietary fiber that exhibit biological activities in the prevention and treatment of HFD-induced metabolic diseases. Of note, natural polysaccharides are among the most potent modulators of the gut microbiota composition. However, the prebiotics-like effects of polysaccharides in treating HFD-induced metabolic diseases remain elusive. In this review, we introduce the critical role of gut microbiota human health and HFD-induced metabolic disorders. Importantly, we review current knowledge about the role of natural polysaccharides in improving HFD-induced metabolic diseases by regulating gut microbiota.

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“…The administration of the probiotic Lactobacillus plantarum, Bifidobacterium breve, and Lactobacillus fermentum to obese mice exposed to Escherichia coli increased the content of SCFAs in the stool by modifying the structure of the microbiota and reducing inflammation [162,163]. The administration of Lactobacillus acidophilus (probiotic bacteria) has been shown to alleviate the effects of obesity in mice by modulating intestinal microbiota dysbiosis and tightening the intestinal mucosa, as well as increasing the activity of Akkermansia muciniphila [164,165]. Consuming foods containing probiotic bacteria has a positive effect on the gastrointestinal microbiome [157,159].…”

Section: Communication Between Microorganisms and Epithelial Cells Re...mentioning

confidence: 99%

The Role of Nutritional Factors in the Modulation of the Composition of the Gut Microbiota in People with Autoimmune Diabetes

et al. 2022

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Type 1 diabetes mellitus (T1DM) is a disease marked by oxidative stress, chronic inflammation, and the presence of autoantibodies. The gut microbiota has been shown to be involved in the alleviation of oxidative stress and inflammation as well as strengthening immunity, thus its’ possible involvement in the pathogenesis of T1DM has been highlighted. The goal of the present study is to analyze information on the relationship between the structure of the intestinal microbiome and the occurrence of T1DM. The modification of the intestinal microbiota can increase the proportion of SCFA-producing bacteria, which could in turn be effective in the prevention and/or treatment of T1DM. The increased daily intake of soluble and non-soluble fibers, as well as the inclusion of pro-biotics, prebiotics, herbs, spices, and teas that are sources of phytobiotics, in the diet, could be important in improving the composition and activity of the microbiota and thus in the prevention of metabolic disorders. Understanding how the microbiota interacts with immune cells to create immune tolerance could enable the development of new therapeutic strategies for T1DM and improve the quality of life of people with T1DM.

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Lactobacillus acidophilus ameliorates obesity in mice through modulation of gut microbiota dysbiosis and intestinal permeability

Cited by 85 publications

References 51 publications

Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression

Specific Gut Microbial Environment in Lard Diet-Induced Prostate Cancer Development and Progression

Targeting Gut Microbiota With Natural Polysaccharides: Effective Interventions Against High-Fat Diet-Induced Metabolic Diseases

The Role of Nutritional Factors in the Modulation of the Composition of the Gut Microbiota in People with Autoimmune Diabetes

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