The Allostatic Load Index (ALI) has been used to establish associations between stress
and health-related outcomes. This review summarizes the measurement and methodological
challenges of allostatic load in occupational settings. Databases of Medline, PubPsych,
and Cochrane were searched to systematically explore studies measuring ALI in working
adults following the PRISMA statement. Study characteristics, biomarkers and methods were
tabulated. Methodological quality was evaluated using a standardized checklist. Sixteen
articles (2003–2013) met the inclusion criteria, with a total of 39 (range 6–17) different
variables used to calculate ALI. Substantial heterogeneity was observed in the number and
type of biomarkers used, the analytic techniques applied and study quality. Particularly,
primary mediators were not regularly included in ALI calculation. Consensus on methods to
measure ALI in working populations is limited. Research should include longitudinal
studies using multi-systemic variables to measure employees at risk for biological wear
and tear.
Background
Inflammation and vagally mediated heart rate variability (vmHRV) have been implicated in a number of conditions including diabetes and cardiovascular disease. Consistent with the inflammatory reflex termed the ‘cholinergic anti‐inflammatory pathway’, numerous cross‐sectional studies have demonstrated negative associations between vmHRV and inflammatory markers such as C‐reactive protein (CRP). The only prospective study, however, showed the opposite: higher CRP at baseline predicted higher high‐frequency heart rate variability (HF‐HRV) at follow‐up. Thus, additional studies are needed to examine the prospective association between vmHRV and CRP.
Methods
Healthy employees participated in a voluntary on‐site health assessment. Blood samples and ambulatory heart rate recordings were obtained, and night‐time HF‐HRV was calculated. Useable heart rate data were available in 2007 for 106 nonsmoking employees (9% women; age 44.4 ± 8 years), all of whom returned for an identical follow‐up health assessment in 2011. Bootstrapped (500 replications) bivariate (r) and partial Pearson's correlations (ppc) adjusting for sex, age and body mass index at baseline (2007) were calculated.
Results
Zero‐order correlations indicated that higher HF‐HRV was associated with lower levels of CRP at both time‐points (2007: r = −0.19, P < 0.05; 2011: r = −0.34, P < 0.001). After adjustment, HF‐HRV remained a significant predictor of CRP (ppc = −0.20, P < 0.05).
Conclusion
In this study, we have provided in vivo support for the cholinergic anti‐inflammatory pathway in humans. Cardiac vagal modulation at baseline predicts level of CRP 4 years later. Our findings have important implications for the role of vmHRV as a risk factor for cardiovascular disease morbidity and mortality. Interventions targeted at vmHRV might be useful in the prevention of diseases associated with elevated systemic inflammation.
The findings indicate that work stress in terms of ERI is associated with diabetes and prediabetes in German industrial male workers. If supported by prospective evidence, results point to a new approach towards primary prevention of diabetes.
BackgroundWork stress is associated with an increased risk of pre-diabetes, Type 2 diabetes, and inflammation, as well as decreased autonomic nervous system function as measured, for example, via heart rate variability. We investigated the extent to which the association between work stress and glycemic status is mediated by vagally-mediated heart rate variability (vmHRV) and/or inflammation.MethodsCross-sectional data from the Mannheim Industrial Cohort Study (MICS) with 9,937 participants were analyzed. The root mean squared successive differences (RMSSD) from long-term heart rate monitoring during work and night time periods was used to index vmHRV. Fasting plasma glucose and glycosylated hemoglobin were assessed to determine glycemic status. High sensitive C-reactive protein levels were observed as a measure of systemic inflammation and the Effort-Reward-Imbalance scale was used to evaluate work stress. Mediation models were adjusted for age, sex, and occupational status, and estimations were bootstrapped (5,000 replications).ResultsEffort-Reward-Imbalance was significantly negatively associated with RMSSD and both glycosylated hemoglobin and fasting plasma glucose during both work and night time periods. Effort-Reward-Imbalance was observed to have a significant direct effect on glycosylated hemoglobin and significant indirect effects, through RMSSD, on both glycemic measures during both time periods. Introducing C-reactive protein as a further mediator to the model did not alter the indirect effects observed. C-reactive protein, as an exclusive mediator, was observed to have smaller direct and indirect effects on the glycemic measures as compared to when Effort-Reward-Imbalance was included in the model.ConclusionsOur results suggest that the association between work stress and glycemic status is partially mediated through vmHRV independent of systemic inflammation as measured by C-reactive protein. We conclude that work stress may be an additional factor that promotes development of hyperglycemic-metabolic states. If supported by prospective evidence, these results may lead to new approaches for primary prevention of hyperglycemia in the workplace.
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