Bronchial asthma and obesity: search for therapeutic models

Fomina, DS; Goriachkina, L A; Алексеева, Ю. Г.; Bobrikova, Elena N.

doi:10.18093/0869-0189-2014-0-6-94-102

Cited by 7 publications

(2 citation statements)

References 61 publications

(67 reference statements)

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“…К числу таких факторов относятся данные о том, что увеличивается число пациентов, страдающих одновременно астмой и ожирением [2]. Предполагается, что ожирение увеличивает риск возникновения БА и изменяет астму в сторону более трудно контролируемого фенотипа, что делает необходимой разработку специального терапевтического подхода при лечении больных с особым феноменом «астма-ожирение» [3,4].…”

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“…Количество генов-кандидатов, которые потенциально могут влиять на различные компоненты как БА, так и ожире-ния, очень велико. Имеются генетические составляющие, частично совпадающие у близнецов, пациентов с астмой и ожирением, в области хромосом 2р, 5q, 6p, 7р, 11q13, 12q.5,8,9, 17q21, что позволяет предположить общую генетическую предрасположенность, поиск ассоциаций которых продолжается [4,6].…”

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Evaluation of the involvement of PPARG2 gene rs1801282 polymorphism in the pathogenesis of bronchial asthma with obesity in children

Telepneva¹,

Евсеева²,

Nagovitsyna³

et al. 2022

Bûlletenʹ fiziologii i patologii dyhaniâ

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Introduction. Features of the clinical course of bronchial asthma in children with obesity made it possible to identify a special phenotype, when the presence and severity of obesity determine a more severe course of asthma and a worse response to asthma therapy. Asthma, like obesity, is recognized as a classic example of multifactorial diseases, which are based on a rather complex gene network. Studying the genetic basis of both of these complex traits and linking them to the asthma phenotype should contribute to our understanding of the overall genetic basis of these pathological disorders.Aim. Evaluation of the clinical and genetic significance of the rs1801282 polymorphism of the PPARG2 gene (34C>G, p.Pro12Ala) in children with asthma and obesity.Materials and methods. 161 children with asthma were examined, including 59 patients with obesity 1-3 degrees. The examination included general clinical, functional, instrumental methods. The level of asthma control was determined according to the GINA criteria (2018). The study of gene polymorphisms was carried out by the real-time polymerase chain reaction.Results. An analysis of the frequencies of the PPARG2 gene polymorphism in children with bronchial asthma did not reveal any differences from the control group healthy people. In 61% of children with asthma and obesity, there was no control over the disease, which was associated with the G allele (OR 2.4 [95% CI: 1.09‒5.30], p=0.0281). An increase in the activity of lactate dehydrogenase and a decrease in the membrane potential of mitochondria in peripheral blood lymphocytes in children with the GG genotype were revealed, which may indirectly affect the level of disease control.Conclusion. The comorbidity of asthma and obesity in children affects the control of the disease. This manifests itself through immune mechanisms that play a key role in energy homeostasis and mitochondrial dysfunction of immunocompetent blood cells. The G-allele of the PPARG2 gene can be a marker of the lack of control over the disease in obese children with asthma. The pathogenetic significance of this polymorphism requires further study.

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Evaluation of the involvement of PPARG2 gene rs1801282 polymorphism in the pathogenesis of bronchial asthma with obesity in children

Telepneva¹,

Евсеева²,

Nagovitsyna³

et al. 2022

Bûlletenʹ fiziologii i patologii dyhaniâ

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Pathogenetic Aspects of the Phenotype of Bronchial Asthma Associated With Obesity

Uksumenko¹,

Антонюк²,

Аntonyuk³

2019

Bulletin Physiology and Pathology of Respiration

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Currently, in parallel with the increase in the prevalence of asthma, there is an increase in the number of obese patients. The results of numerous studies indicate that the asthma phenotype in combination with obesity has well-defined clinical features – a more severe course with frequent exacerbations and reduced control of the disease. The article considers the main pathogenetic mechanisms that determine the development of the asthma phenotype in combination with obesity. The influence of excess adipose tissue in the chest on respiratory mechanics, the correlation of gastroesophageal reflux disease and respiratory depression in sleep are described. It is shown that the phenotype of asthma with obesity is characterized by inflammation of adipose tissue, adipokine imbalance, insulin resistance, and disturbance of vitamin D metabolism. Gender peculiarities and genetic condition of asthma associated with obesity are considered. Understanding general mechanisms underlying the formation of asthma and obesity will undoubtedly contribute to the development of new therapeutic strategies.

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Thickness of epicardial fat tissue as a marker of various obesity phenotypes in young patients with bronchial asthma

Соловьева¹,

Демко²,

Собко³

et al. 2020

Pulʹmonologiâ (Mosk.)

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Bronchial asthma and obesity: search for therapeutic models

Cited by 7 publications

References 61 publications

Evaluation of the involvement of PPARG2 gene rs1801282 polymorphism in the pathogenesis of bronchial asthma with obesity in children

Evaluation of the involvement of PPARG2 gene rs1801282 polymorphism in the pathogenesis of bronchial asthma with obesity in children

Pathogenetic Aspects of the Phenotype of Bronchial Asthma Associated With Obesity

Thickness of epicardial fat tissue as a marker of various obesity phenotypes in young patients with bronchial asthma

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