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Neshasteh-riz (2019) Investigating the effect of near infrared photo thermal therapy folic acid conjugated gold nano shell on melanoma cancer cell line A375, Artificial Cells,

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Nowadays, gold nanoshells are used in targeted nano photothermal cancer therapy. This study surveyed the application of gold nanoshell (GNs) to thermal ablative therapy for melanoma cancer cells and it takes advantage of the near infrared absorption of gold nanoshells. The synthesis and characterization of glycosylated gold nanoshells (GGNs) were done. The cytotoxicity and photothermal effects of GNs on melanoma cells were evaluated using MTT assay and flow cytometry. The characterization data showed that GGNs are spherical, with a hydrodynamic size of 46.7 nm. Results suggest that the cellular uptake of GGNs was about 78%. Viability assays showed no significant toxicity at low concentrations of GNs. The higher heating rate and toxicity of cancer cells were obtained for the cells exposed to 808 nm NIR laser after incubation with GGNs rather than the GNs. The viability of these cells has dramatically decreased by 29%. Furthermore, 61% more cell lethality was achieved for A375 cells using combined photothermal therapy and treatment with GGNs in comparison to NIR radiation alone. In conclusion, our findings suggest that the synthesized gold/silica core-shell nanoparticles conjugated with glucosamine have high potentials to be considered as an efficient metal-nanoshell in the process of targeted cancer photothermal therapy.

We present the design, fabrication, and characterization of an infrared (IR) polarization sensing detector with a wide dynamic range and sub-wavelength dimensions. The detector consists of two orthogonal slot antennas, each loaded with two microbolometers at its edges. The polarization of the incoming IR radiation is detected by comparing the received power levels in the bolometer pairs corresponding to each slot antenna. The IR radiation is sensed by applying a dc bias voltage to each antenna and measuring the changes in the dc current caused by the change of the bolometer resistance as they absorb the incoming IR radiation. In this design, the ratio of the absorbed power in the bolometers is a one to one function of the polarization of the incident wave. A prototype of this detector, designed to have maximum sensitivity at λ = 10.6 μm, was designed, fabricated, and characterized. The fabricated detector has an area of 0.7λ × 0.7λ, where λ is the free-space wavelength. The polarization sensing response is characterized under different angles of incidence. The measurement results show that the device has a dynamic range of 24 dB between two orthogonal orientations of EM wave polarization for incidence angles in the range of ±20° from boresight.

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