Motivated by the rapid development of heavyflavor experiments, phenomenological studies of nonleptonic and are in the scope of Belle-II and LHCb experiments. Moreover, they also provide a way to crosscheck the possible puzzles mentioned above through the similar ratios R V ds and R V / ν . More refined experimental measurements and theoretical efforts are required to confirm or refute such two anomalies.

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Acid–base bifunctional ionic hybrids were employed as catalysts for glucose dehydration to HMF via a unique sequential hydrogen transfer route.

Purpose Corticosteroids are regarded as the mainstay of medical treatment of eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP). To date, a head-to-head comparison of the efficacy and safety of glucocorticoid preparations administered via different routes for the treatment of chronic rhinosinusitis with nasal polyps has not been reported. To compare the efficacy and safety of steroids administered via the oral, intranasal spray and transnasal nebulization routes in the management of ECRSwNP over a short course. Methods Overall, 91 patients with ECRSwNP were recruited prospectively and randomized to receive either oral methylprednisolone, budesonide inhalation suspension (BIS) via transnasal nebulization, or budesonide nasal spray (BNS) for 2 weeks. Nasal symptoms and polyp sizes were assessed before and after the treatment. Similarly, nasal polyp samples were evaluated for immunological and tissue remodeling markers. Serum cortisol levels were assessed as a safety outcome. Results Oral methylprednisolone and BIS decreased symptoms and polyp sizes to a significantly greater extent from baseline ( P < 0.05) than BNS. Similarly, BIS and oral methylprednisolone significantly reduced eosinophils, T helper 2 cells, eosinophil cationic protein, interleukin (IL)-5, and expression of matrix metalloproteinases 2 and 9, and significantly increased type 1 regulatory T cells, IL-10, transforming growth factor-β, and tissue inhibitor of metalloproteinases 1 and 2 in nasal polyps to a greater extent than BNS. Post-treatment serum cortisol levels were significantly decreased by oral methylprednisolone compared to BIS or BNS, which did not significantly alter the cortisol levels. Conclusions A short course of BIS transnasal nebulization is more efficacious compared to BNS in the management of ECRSwNP and is safer than oral methylprednisolone with respect to hypothalamic-pituitary-adrenal axis function.

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A large body of literature has examined the relations between social support and depression. However, the exact nature and direction of these relations are not well understood. This study explored the relations between specific types of social support (peer support and teacher support) and depression. Adolescents (ages 11 to 17) for the first time (N = 2453) participated in a two-wave, 6-month longitudinal study. Structural equation modeling was used to test a social causation model (deficits in social support increase the likelihood of depression), interpersonal theories of depression (depression leads to social erosion), and a reciprocal influence model. Depression influenced peer support significantly and negatively. By contrast, the social causation model was not supported. These results held for males and females. Findings suggested that depression resulted in social support erosion. However, the effect was specific to perceived peer support but not to perceived teacher support.

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